A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Narasimha Reddy, Y.
- Evaluation of Antiulcer Activity of Coccinia grandis Leaves
Authors
1 Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, IN
2 MAM College of Pharmacy, Narsaraopet, Guntur, IN
3 University College of Pharmaceutical Sciences, Kakatiya University, Warangal, IN
4 Dept of Biochemistry S.V. University, Tirupati.517-501, IN
5 Sri Padmavathi School of Pharmacy, Tirupati, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 2 (2011), Pagination: 92-95Abstract
The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.Keywords
Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.References
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- Prevalence and Antimicrobial Resistance Pattern of Shiga Toxigenic Escherichia coli in Diarrheic Buffalo Calves
Authors
1 Department of Veterinary Microbiology, NTR College of Veterinary Science, Gannavaram, Krishna - 521 101, Andhra Pradesh, IN
2 Department of Veterinary Microbiology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, IN
3 Directorate of Poultry Research, Rajendranagar, Hyderabad, Telangana, IN
4 Department of Veterinary Public Health, NTR College of Veterinary Science, Gannavaram, Andhra Pradesh, IN
Source
Veterinary World, Vol 10, No 7 (2017), Pagination: 774-778Abstract
Aim: Aim of the study was to investigate the prevalence, virulence gene profiles, and antimicrobial resistance pattern of Shiga toxigenic Escherichia coli (STEC) in diarrheic buffalo calves from Andhra Pradesh and Telangana States.
Materials and Methods: A total of 375 fecal samples from diarrheic buffalo calves of 1-7, 8-30, 31-60, and 61-90 days age were collected from which STEC were isolated, and virulence genes were detected using multiplex polymerase chain reaction. The antimicrobial resistance of isolates was tested by disk diffusion method.
Results: The prevalence of E. coli associated diarrhea in buffalo calves was 85.04%, of which 35.01% was STEC origin. In STEC, the combination of eaeA and, hlyA virulence genes was highest (42.45%) followed by stx1 (16.04%), stx1, stx2 and hlyA (13.21%), stx2 (12.64%), stx1, eae and hlyA (9.43%) and stx1 and hlyA (6.6%) genes were detected. Highest antimicrobial resistance was observed for tetracycline (63.21%) and ampicillin (48.11%), while chloramphenicol, gentamycin (96.33%) and imipenem (99.06%) antibiotics are susceptible. Multidrug resistance was detected in 69.81% of the STEC isolates from diarrheic buffalo calves.
Conclusion: Higher prevalence of eaeA and hlyA genes carrying isolates of STEC may be a serious zoonotic threat and increased prevalence of multidrug resistance in E. coli may necessitate stringent selection of appropriate antimicrobial agent in treating buffalo calf diarrhea cases.